Summary Bedaquiline is used to treat multi-resistant tuberculosis in adults. The fumarate salt is commercially available and used in the product Sirturo. To provide open access to bedaquiline molecule once the patent on the chemical substance expires, new salts were screened. The current studies focus on the attempted isolation of the acetate, benzoate, benzenesulfonate, hydrobromide, […]
Summary Bedaquiline is one of two important new drugs for the treatment of drug-resistant tuberculosis (TB). It is marketed in the US as its fumarate salt, but only a few salts of bedaquiline have been structurally described so far. We present here five crystal structures of bedaquilinium maleate. Dale K. Purcell, Ph.D. of Chemical Microscopy […]
Bedaquiline is one of two important new drugs for the treatment of drug-resistant tuberculosis (TB). This paper discusses the crystalline structure of three salts of bedaquiline. Dale K. Purcell, Ph.D. of Chemical Microscopy LLC performed the spectroscopic analyses as reported.
Our founder, Dr. Dale Purcell, will provide his perspective on the importance that vibrational spectroscopy and other chemical microscopy techniques provide for a pharmaceutical forensic scientist. This presentation will be on Thursday, November 19, 2020 at 2:00 PM during the 2020 Eastern Analytical Symposium and Exposition. Chemical microscopy and microspectroscopy in a pharmaceutical laboratory enjoy […]
Take a video tour of our office located at the Kurz Purdue Technology Center in West Lafayette, Indiana. We have laboratory space in that facility which makes it easy to collaborate with other companies in the Park.
Frost & Sullivan recently published a review of the materials characterization market. In this global review, they covered the technologies of physical testing analyzers, thermal analyzers, particle characterization systems, and more. This analysis looked at pharmaceutical, petrochemical, polymer, automotive, food, and cosmetic sectors. This market could expand to $2.28 Billion by 2024. To read more, […]