Nirmatrelvir methyl tert-butyl ether solvate

The structure of nirmatrelvir MTBE solvate, C23H32F3N5O4·C5H12O, at 150 K has monoclinic (P21) symmetry. The asymmetric unit contains one nirmatrelvir mol­ecule and one methyl tert-butyl ether solvent mol­ecule. The extended structure consists of N—H⋯O hydrogen bonds that create [010] chains. Crystals of the title compound were grown from various methyl tert-butyl ether–methanol solvent mixtures, with crystal morphology dependent upon the mixture ratio.