Salts and Polymorph Screens for Bedaquiline

Maleate salts of bedaquiline

Summary Bedaquiline is used to treat multi-resistant tuberculosis in adults. The fumarate salt is commercially available and used in the product Sirturo. To provide open access to bedaquiline molecule once the patent on the chemical substance expires, new salts were screened. The current studies focus on the attempted isolation of the acetate, benzoate, benzenesulfonate, hydrobromide, […]

Maleate salts of bedaquiline

Maleate salts of bedaquiline

Summary Bedaquiline is one of two important new drugs for the treatment of drug-resistant tuberculosis (TB). It is marketed in the US as its fumarate salt, but only a few salts of bedaquiline have been structurally described so far. We present here five crystal structures of bedaquilinium maleate. Dale K. Purcell, Ph.D. of Chemical Microscopy […]

Crystal structures of salts of bedaquiline

Crystal structures of salts of bedaquiline

Bedaquiline is one of two important new drugs for the treatment of drug-resistant tuberculosis (TB). This paper discusses the crystalline structure of three salts of bedaquiline. Dale K. Purcell, Ph.D. of Chemical Microscopy LLC performed the spectroscopic analyses as reported.